Conocimientos básicos sobre la toxina botulínica para una utilización terapéutica segura

Autores/as

  • María Victoria Morales Salucoop, Hospital General de Medellín.
  • Kelly Payares Universidad de Antioquia
  • Andrés Zuluaga Universidad de Antioquia

Palabras clave:

biológicos, toxina botulínica tipo A, margen de seguridad, margen terapéutico, migración.

Resumen

El conocimiento específico de las diferentes características moleculares, fisicoquímicas y farmacológicas de cada producto biológico de toxina botulínica tipo A (BoNTA), disponible en nuestro mercado, es indispensable para asegurar una adecuada prescripción con el mínimo de eventos adversos.

La BoNTA tiene indicaciones en múltiples condiciones clínicas, las cuales están autorizadas por agencias reguladoras de importancia como FDA (del inglés, Food and Drug Administration) en Estados Unidos o EMA (del inglés European Medicine Agency) en Europa, e INVIMA (Instituto Nacional de Vigilancia de Medicamentos y Alimentos) en Colombia.


Al comparar las características generales de los diferentes productos disponibles de BoNTA, se puede concluir que son entidades biológicas similares, no idénticas, con potencias diferentes, las cuales determinan un perfil de eficacia y seguridad específica para cada producto. Por esta razón no son intercambiables, y el uso clínico debe ser individualizado según la condición clínica del paciente, además del producto a utilizar y de la experiencia en el método de inyección utilizado por el médico tratante.

Biografía del autor/a

María Victoria Morales, Salucoop, Hospital General de Medellín.

Salucoop, Hospital  General   de  Medellín.

Kelly Payares, Universidad de Antioquia

Profesora titular. Grupo Rehabilitación en Salud, Departamento de Medicina Física y Rehabilitación. Facultad de Medicina.

Andrés Zuluaga, Universidad de Antioquia

Profesor asociado. GRIPE (Grupo Investigador de Problemas en Enfermedades Infecciosas), Departamento de Farmacología y Toxicología, Facultad de Medicina.

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Cómo citar

1.
Morales MV, Payares K, Zuluaga A. Conocimientos básicos sobre la toxina botulínica para una utilización terapéutica segura. Rev. Colomb. Med. Fis. Rehabil. [Internet]. 15 de diciembre de 2013 [citado 28 de marzo de 2024];23(2):106-18. Disponible en: https://revistacmfr.org/index.php/rcmfr/article/view/71

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Publicado

2013-12-15

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Revisión sistemática
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