Effectiveness and safety profile of extended release Tramadol for the control of pain in patients with osteoarthritis in the lumbar region, hip, knee and/or hands. Experience of a group of Colombian Physiatrists.
Keywords:
sustained release Tramadol, osteoarthritis, drug utilization study.Abstract
Objectives: to determine the analgesic effectiveness and safety of extended release Tramadol (Tramal Long ) in osteoarthritis (hip,knee, low back and hand) in patients from different cities of Colombia.
Methods: observational, descriptive, longitudinal, prospective it included 123 patients. Drug Utilization Study analyzing patterns associated with drug use and evaluation of clinical outcomes.
Results: the average age was 61.55 years, 68% of patientswerewomen, 88% of patients had a single diagnosis, most frequent diagnosis was lumbar osteoarthritis 46% followed by knee osteoarthritis with 34 %. Median pain assessed
by Visual Analogue Scale (VAS) at baseline was 8 (IQ95% 5 - 10) in the first control (30 days)was 4 (IQ95% 1 - 8) and at the end of the second control (60 days) was 2 (IQ 95% 0 - 8). On
security issues, 64% (79) of patients did not experience any adverse event in the first control visit, while 78% (96) of patients did not report adverse events at the final visit.
Conclusions: the results suggest that extended release Tramadol is a therapeutic option that shows effectiveness and favorable safety profile in osteoarthritis painmanagement.
References
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2. Haq I. Osteoarthritis. Postgraduate Medical Journal 2003;79:377-383.
3. Moskowitz R.Osteoarthritis: simple analgesics versus nonsteroidal antiinflammatory drugs. Rheumatol. 2001; 28: 932 - 934.
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7. Burch F. A Comparison of the analgesic Efficacy of Tramadol Versus Placebo in Patients with Pain due to Osteoarthritis. J o u r n a l of pa i n and Symptom Management. 2007; 34(3): 328-38.
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10. Iglehart JK. Prioritizing Comparative- Ef fe c t i v e n e s s Re s e a r ch – IOM Recommendations. New England Journal of Medicine 2009; 361(4): 325-328.
2. Haq I. Osteoarthritis. Postgraduate Medical Journal 2003;79:377-383.
3. Moskowitz R.Osteoarthritis: simple analgesics versus nonsteroidal antiinflammatory drugs. Rheumatol. 2001; 28: 932 - 934.
4. Adler L. A Comparision of Once-daily Tramadol with normal release Tramadol in the treatment of pain in Osteoarthritis. J Rheumatol. 2002; 29: 2196-2199.
5. Vorsanger G. Post Hoc Analysis of a Randomized, Double-blind, Placebocontrolled Efficacy and Tolerability Study of Tramadol Extended Release for the treatment of Osteoarthritis Pain in Geriatric Patients. Clinical Therapeutics. 2007; 27: 2520-2535.
6. Mongin G. Efficacy and safety Assessment of aNovel Once-Daily Tablet Formulation of Tramadol. Clin Drug Invest. 2004; 24(9): 545-558.
7. Burch F. A Comparison of the analgesic Efficacy of Tramadol Versus Placebo in Patients with Pain due to Osteoarthritis. J o u r n a l of pa i n and Symptom Management. 2007; 34(3): 328-38.
8. Abásolo L, Carmona L. Revisión sistemática: ¿son eficaces los opiáceos mayores en el tratamiento del dolor osteomuscular?. MedClin (Barc). 2007; 128(8): 291-301.
9. Das SK. Osteoarthritis. Best Practice & Research Clinical Rheumatology 2008; 22 (4): 657–675.
10. Iglehart JK. Prioritizing Comparative- Ef fe c t i v e n e s s Re s e a r ch – IOM Recommendations. New England Journal of Medicine 2009; 361(4): 325-328.
How to Cite
1.
Medina JR, Mazzeneth J, Avella F, Rodríguez A, Forero JP, Méndez S, et al. Effectiveness and safety profile of extended release Tramadol for the control of pain in patients with osteoarthritis in the lumbar region, hip, knee and/or hands. Experience of a group of Colombian Physiatrists. Rev. Colomb. Med. Fis. Rehabil. [Internet]. 2012 Apr. 19 [cited 2024 May 17];19(2):28-33. Available from: https://revistacmfr.org/index.php/rcmfr/article/view/34
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